MUTATION IN THE TWO-COMPONENT REGULATOR BAESR MEDIATES CEFIDEROCOL RESISTANCE AND ENHANCES VIRULENCE IN ACINETOBACTER BAUMANNII

Mutation in the two-component regulator BaeSR mediates cefiderocol resistance and enhances virulence in Acinetobacter baumannii

ABSTRACT Acinetobacter baumannii has become one of the most challenging pathogens in many countries with limited treatment options available.Cefiderocol, a novel siderophore-conjugated cephalosporin, shows potent in vitro activity against A.baumannii, including isolates resistant to carbapenems.To date, few reports on the mechanisms of cefiderocol

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More Testing of Mesoamerican Lunate Artifacts as Possible Loom Weights, that also Functioned as Twining Tools

In previous replication studies and experiments, a lunate jade artifact from the Pre-Classic/Formative period (1500 Vacuum Bags BC-AD 250) of Mesoamerica was analysed, researched, and tested for its similarities to the crescent weight, a specialized type of loom weight found in ancient Central and Southern Europe.These analyses successfully establi

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Mitochondrial genome of Trichagalma acutissimae (Hymenoptera: Cynipoidea: Cynipidae) and phylogenetic analysis

Trichagalma acutissimae (Monzen) (Hymenoptera: Cynipidae) is GREEN TEA a major pest of Quercus variabilis Blume in the Taihang Mountains in China.In this study, we sequenced and analyzed the mitochondrial genome (mitogenome) of T.acutissimae.This mitogenome was 16,078 bp long and encoded 13 protein-coding genes (PCGs), 22 transfer RNA genes (tRNAs)

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